Chemistry xii

Textbook of Inorganic Chemistry for JEE Main &...

Hageman factor was first discovered in 1955 when a routine preoperative blood sample of the 37-year-old railroad brakeman John Hageman (1918) was found to have prolonged clotting time in test tubes, even though he had no hemorrhagic symptoms. Hageman was then examined by hematologist Oscar Ratnoff , who found that Hageman lacked a previously unidentified clotting factor. [13] Ratnoff later found that the Hageman factor deficiency is an autosomal recessive disorder, after examining several related people who had the deficiency. Paradoxically, pulmonary embolism contributed to Hageman's death after an occupational accident. Since then, case studies and clinical studies identified an association between thrombosis and Factor XII deficiency. Hepatocytes express blood coagulation factor XII. [14]

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chemistry xii

Chemistry xii

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chemistry xii

Chemistry xii

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chemistry xii

Chemistry xii

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chemistry xii
Chemistry xii

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Chemistry xii

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chemistry xii

Chemistry xii

Hageman factor was first discovered in 1955 when a routine preoperative blood sample of the 37-year-old railroad brakeman John Hageman (1918) was found to have prolonged clotting time in test tubes, even though he had no hemorrhagic symptoms. Hageman was then examined by hematologist Oscar Ratnoff , who found that Hageman lacked a previously unidentified clotting factor. [13] Ratnoff later found that the Hageman factor deficiency is an autosomal recessive disorder, after examining several related people who had the deficiency. Paradoxically, pulmonary embolism contributed to Hageman's death after an occupational accident. Since then, case studies and clinical studies identified an association between thrombosis and Factor XII deficiency. Hepatocytes express blood coagulation factor XII. [14]

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chemistry xii

Chemistry xii

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chemistry xii

Chemistry xii

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Chemistry xii

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Chemistry xii

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